Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension.

Abstract excerpt

A recently discovered family of protein kinases is responsible for an autosomal-dominant disease known as Gordon's syndrome or pseudohypoaldosteronism type II (PHA-II) that features hyperkalemia and hyperchloremic metabolic acidosis, accompanied by hypertension and hypercalciuria. Four genes have been described in this kinase family, which has been named WNK, due to the absence of a key lysine in kinase subdomain...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Down-Regulation
• Share to Hypertension
• Share to Ion Transport