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Article

Pseudohypoaldosteronism Type II: A Young Girl Presented with Hypertension, Hyperkalemia and Metabolic Acidosis.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP - 1 Mar 2018

Sethar Gul Hassan, Almoghawi Aisha, Khan Nargis, Altourah Wehad, Ashour Najat Mohammed

Abstract excerpt

Pseudohypoaldosteronism (PHA) type II is an extremely rare disorder which presents with hypertension, hyperkalemia, and normal anion gap metabolic acidosis. PHA II is also known as familial hyperkalemic hypertension, Gordon syndrome, and chloride shunt syndrome. PHA II is an autosomal dominant disorder and is caused by mutation in WNK1, WNK4, CULLIN3, KLHL3, OSR, SPAK gene. The expression of these proteins is...

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Source

Identifiers

PMID: 29482694
DOI: 10.29271/jcpsp.2018.03.S21

Genes

KLHL3
WNK1
WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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