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Predicting isoniazid resistance in Mycobacterium tuberculosis complex in New York State using whole-genome sequencing.

Journal of clinical microbiology - 8 Apr 2026

Patel Kruthikaben, Shea Joseph, Lapierre Pascal, Halse Tanya A, Kohlerschmidt Donna, Dickinson Michelle, Escuyer Vincent, Musser Kimberlee A

Abstract excerpt

Isoniazid (INH) is a critical antibiotic used worldwide for the treatment and prophylaxis of tuberculosis. Drug resistance (DR) to INH is the single most common type of DR, mediated by multiple genes/loci, including katG, inhA, mabA, mabA-inhA, and the oxyR-ahpC intergenic region. Over the course of 6 years, we performed a two-phase study of 3,696 Mycobacterium tuberculosis complex (MTBC) strains, aiming to...

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PMID: 41848297
DOI: 10.1128/jcm.01609-25
PMCID: PMC13059772

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