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Article

NF1 mutation may be associated with lung-tropic metastasis in cutaneous melanoma: a genomic analysis of 520 patients.

Clinical & experimental metastasis - 6 Jun 2026

Akpalamut Doğancan

Abstract excerpt

BACKGROUND: Metastatic organotropism in cutaneous melanoma remains incompletely understood at the genomic level. While prior work has linked BRAF and NRAS mutations to organ-specific metastasis patterns, the role of NF1 has not been systematically evaluated. We investigated whether NF1 mutation is specifically associated with lung metastasis in cutaneous melanoma. METHODS: We analyzed 520 patients with metastatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42251234
DOI: 10.1007/s10585-026-10413-1

Genes

NF1
BRAF
IMPACT
MET
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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