Article
Molecular characterization of a selected cohort of patients affected by pulmonary metastases of malignant melanoma: Hints from BRAF, NRAS and EGFR evaluation.
Oncotarget - 14 Aug 2015
Ulivieri Alessandra, Cardillo Giuseppe, Manente Liborio, Paone Gregorino, Mancuso Andrea Petricca, Vigna Leonardo, Di Stasio Enrico, Gasbarra Rita, Girlando Salvatore, Leone Alvaro
Abstract excerpt
BACKGROUND: Melanoma is highly curable in early stages but holds devastating consequences in advanced phases with a median survival of 6-10 months. Lungs are a common metastasis target, but despite this, limited data are available on the molecular status of pulmonary lesions. MATERIALS AND METHODS: 25 patients with surgically resected melanoma lung metastases were screened for BRAF, NRAS, CKIT and EGFR...
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