Article
Genomic and Transcriptomic Analyses of NF1-Mutant Melanoma Identify Potential Targeted Approach for Treatment.
The Journal of investigative dermatology - 1 Mar 2023
Jour George, Illa-Bochaca Irineu, Ibrahim Milad, Donnelly Douglas, Zhu Kelsey, Miera Eleazar Vega-Saenz de, Vasudevaraja Varshini, Mezzano Valeria, Ramswami Sitharam, Yeh Yu-Hsin, Winskill Carolyn, Betensky Rebecca A, Mehnert Janice, Osman Iman
Abstract excerpt
There is currently no targeted therapy to treat NF1-mutant melanomas. In this study, we compared the genomic and transcriptomic signatures of NF1-mutant and NF1 wild-type melanoma to reveal potential treatment targets for this subset of patients. Genomic alterations were verified using qPCR, and differentially expressed genes were independently validated using The Cancer Genome Atlas data and...
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