Article
Lung-only melanoma: UV mutational signature supports origin from occult cutaneous primaries and argues against the concept of primary pulmonary melanoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2020
Yang Chen, Sanchez-Vega Francisco, Chang Jason C, Chatila Walid K, Shoushtari Alexander N, Ladanyi Marc, Travis William D, Busam Klaus J, Rekhtman Natasha
Abstract excerpt
Primary pulmonary melanoma (PPM) is an entity recognized by the thoracic WHO classification. However, given the absence of native melanocytes in the lung and the known phenomenon of regression of cutaneous melanomas, the existence of PPM has remained controversial. Herein we investigate clinicopathologic and genomic features of lung-only melanomas with the goal to clarify their site of origin. We identified 10...
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