Article
Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation.
Structure (London, England : 1993) - 3 Apr 2018
Lecointre Céline, Simon Valérie, Kerneur Clément, Allemand Frédéric, Fournet Aurélie, Montarras Ingrid, Pons Jean-Luc, Gelin Muriel, Brignatz Constance, Urbach Serge, Labesse Gilles, Roche Serge
Abstract excerpt
The pseudo-kinase and signaling protein Pragmin has been linked to cancer by regulating protein tyrosine phosphorylation via unknown mechanisms. Here we present the crystal structure of the Pragmin 906-1,368 amino acid C terminus, which encompasses its kinase domain. We show that Pragmin contains a classical protein-kinase fold devoid of catalytic activity, despite a conserved catalytic lysine (K997). By...
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