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Pan-cancer analysis of PTPN6: prognostic significance and functional implications in tumor progression

25 Aug 2025

Abstract excerpt

BACKGROUND: Cancer remains a leading cause of mortality worldwide, characterized by complex genetic and molecular alterations. The Protein Tyrosine Phosphatase Non-Receptor Type 6 (PTPN6), also known as SHP-1, plays a critical role in regulating immune responses and cellular signaling pathways, with emerging evidence suggesting its involvement in cancer progression. Previous studies have linked aberrant PTPN6...

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PMID: 40853435
DOI: 10.1007/s12672-025-03384-4

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