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Article

PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis.

Nature communications - 8 Jun 2021

Yin Shasha, Liu Liu, Brobbey Charles, Palanisamy Viswanathan, Ball Lauren E, Olsen Shaun K, Ostrowski Michael C, Gan Wenjian

Abstract excerpt

AKT is involved in a number of key cellular processes including cell proliferation, apoptosis and metabolism. Hyperactivation of AKT is associated with many pathological conditions, particularly cancers. Emerging evidence indicates that arginine methylation is involved in modulating AKT signaling pathway. However, whether and how arginine methylation directly regulates AKT kinase activity remain unknown. Here we...

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Identifiers

PMID: 34103528
DOI: 10.1038/s41467-021-23833-2
PMCID: PMC8187744

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