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HDAC6 Substrate Discovery Using Proteomics-Based Substrate Trapping: HDAC6 Deacetylates PRMT5 to Influence Methyltransferase Activity.

ACS chemical biology - 20 Aug 2021

Gomes Inosha D, Ariyaratne Udana V, Pflum Mary Kay H

Abstract excerpt

Histone deacetylase 6 (HDAC6) is upregulated in a variety of tumor cell lines and has been linked to many cellular processes, such as cell signaling, protein degradation, cell survival, and cell motility. HDAC6 is an enzyme that deacetylates the acetyllysine residues of protein substrates, and the discovery of HDAC6 substrates, including tubulin, has revealed many roles of HDAC6 in cell biology. Unfortunately,...

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PMID: 34314149
DOI: 10.1021/acschembio.1c00303
PMCID: PMC8939004

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