Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor.

eLife - 16 May 2016

Mounir Zineb, Korn Joshua M, Westerling Thomas, Lin Fallon, Kirby Christina A, Schirle Markus, McAllister Gregg, Hoffman Greg, Ramadan Nadire, Hartung Anke, Feng Yan, Kipp David Randal, Quinn Christopher, Fodor Michelle, Baird Jason, Schoumacher Marie, Meyer Ronald, Deeds James, Buchwalter Gilles, Stams Travis, Keen Nicholas, Sellers William R, Brown Myles, Pagliarini Raymond A

Abstract excerpt

The TMPRSS2:ERG gene fusion is common in androgen receptor (AR) positive prostate cancers, yet its function remains poorly understood. From a screen for functionally relevant ERG interactors, we identify the arginine methyltransferase PRMT5. ERG recruits PRMT5 to AR-target genes, where PRMT5 methylates AR on arginine 761. This attenuates AR recruitment and transcription of genes expressed in differentiated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Methylation
Share to Oncogene Proteins, Fusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prostate

Share to Protein-Arginine N-Methyltransferases

Share to Protein Interaction Domains and Motifs

Share to Receptors, Androgen

Share to Serine Endopeptidases

Share to Transcriptional Regulator ERG

Source

Open in PubMed Open full text

Identifiers

PMID: 27183006
DOI: 10.7554/eLife.13964
PMCID: PMC4909395

Genes

ERG
PRMT5
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor.PMID 27183006Read ↗

A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancerSemantic proximity Read ↗

EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancerSemantic proximity Read ↗

Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancerSemantic proximity Read ↗

Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate CancerSemantic proximity Read ↗

Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumorsSemantic proximity Read ↗

ERG Induces Epigenetic Activation of Tudor Domain-Containing Protein 1 (TDRD1) in ERG Rearrangement-Positive Prostate CancerSemantic proximity Read ↗

Protein Arginine Methyltransferase 5 (PRMT5) Mutations in Cancer Cells.Semantic proximity Read ↗

ETS transcription factor ERG cooperates with histone demethylase KDM4ASemantic proximity Read ↗

PRMT5-exacerbating tumor stemness and immunosuppression confer a novel immunotherapeutic vulnerability in aggressive prostate cancerSemantic proximity Read ↗

ERG orchestrates chromatin interactions to drive prostate cell fate reprogrammingSemantic proximity Read ↗

Protein Arginine Methyltransferase 6 Enhances Polyglutamine-Expanded Androgen Receptor Function and Toxicity in Spinal and Bulbar Muscular AtrophySemantic proximity Read ↗

High levels of 5-hydroxymethylcytosine (5hmC) is an adverse predictor of biochemical recurrence after prostatectomy in ERG-negative prostate cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.