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Article

An S752D activation loop mutation dynamically primes Muscle-Specific Kinase for activation.

The Biochemical journal - 8 Jul 2026

Prömer Jakob J, Murphy James W, Lemmon Mark A, Tsutsui Yuko, Herbst Ruth

Abstract excerpt

Muscle-Specific Kinase (MuSK) is a receptor tyrosine kinase essential for neuromuscular junction (NMJ) formation and maintenance, yet its regulation remains poorly understood. Crystallographic studies of wild-type MuSK revealed an autoinhibited conformation with tyrosines in the activation loop (A-loop) anchored within the catalytic cleft to stabilize the closed, inactive conformation. We showed previously that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42240394
DOI: 10.1042/BCJ20260159
PMCID: PMC13305817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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