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Article

An allosteric interaction controls the activation mechanism of SHP2 tyrosine phosphatase.

Scientific reports - 28 Oct 2020

Anselmi Massimiliano, Hub Jochen S

Abstract excerpt

SHP2 is a protein tyrosine phosphatase (PTP) involved in multiple signaling pathways. Mutations of SHP2 can result in Noonan syndrome or pediatric malignancies. Inhibition of wild-type SHP2 represents a novel strategy against several cancers. SHP2 is activated by binding of a phosphopeptide to the N-SH2 domain of SHP2, thereby favoring dissociation of the N-SH2 domain and exposing the active site on the PTP...

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Identifiers

PMID: 33116231
DOI: 10.1038/s41598-020-75409-7
PMCID: PMC7595171

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