Article

An allosteric interaction controls the activation mechanism of SHP2 tyrosine phosphatase

2020-03-25

Abstract excerpt

<h4>ABSTRACT</h4> SHP2 is a protein tyrosine phosphatase (PTP) involved in multiple signaling pathways. Mutations of SHP2 can result in Noonan syndrome or pediatric malignancies. Inhibition of wild-type SHP2 represents a novel strategy against several cancers. SHP2 is activated by binding of a phosphopeptide to the N-SH2 domain of SHP2, thereby favoring dissociation of the N-SH2 domain and exposing the active sit...

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Literature Corpus work: dd1056d2-6562-5a55-afb6-9c56bf9d5b84
DOI: 10.1101/2020.03.24.004911

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