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Article

Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment.

The EMBO journal - 6 Sept 2006

Jauch Ralf, Cho Min-Kyu, Jäkel Stefan, Netter Catharina, Schreiter Kay, Aicher Babette, Zweckstetter Markus, Jäckle Herbert, Wahl Markus C

Abstract excerpt

Autoinhibition is a recurring mode of protein kinase regulation and can be based on diverse molecular mechanisms. Here, we show by crystal structure analysis, nuclear magnetic resonance (NMR)-based nucleotide affinity studies and rational mutagenesis that nonphosphorylated mitogen-activated protein (MAP) kinases interacting kinase (Mnk) 1 is autoinhibited by conversion of the activation segment into an...

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Identifiers

PMID: 16917500
DOI: 10.1038/sj.emboj.7601285
PMCID: PMC1560367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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