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Article

The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2.

Protein science : a publication of the Protein Society - 1 Dec 2025

van Vlimmeren Anne E, Jiang Ziyuan, Karandur Deepti, Applebaum Licht Anya T, Shah Neel H

Abstract excerpt

Dysregulation of the phosphatase SHP2 is implicated in various diseases, including congenital disorders and cancer. SHP2 contains two phosphotyrosine-recognition domains (N-SH2 and C-SH2) and a protein tyrosine phosphatase (PTP) domain. The N-SH2 domain is critical for SHP2 regulation. In the auto-inhibited state, it binds to the PTP domain and blocks the active site, but phosphoprotein engagement destabilizes...

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PMID: 41225768
DOI: 10.1002/pro.70373
PMCID: PMC12611872

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