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Article

LASER couples damage sensing to ESCRT assembly for lysosome repair.

Nature - 1 Aug 2026

Goul Claire S, Jain Aakriti, Yitiz Samira, Soltani Zahra E, Yang Serim, Rapp Simon, Spacci Martina, Federman Scot, Sacco James, Li Huinan, Enriquez Lauren D, Liv Nalan, Przybyla Laralynne, Zoncu Roberto

Abstract excerpt

Lysosomal membrane integrity is essential for cell survival, but how damage sensing is spatiotemporally coupled to repair remains poorly understood. Recruitment and assembly of endosomal sorting complex required for transport (ESCRT) I-III rapidly counteracts membrane damage, but it is unclear how ESCRT-I recognizes defective lysosomal membranes. Here, leveraging genome-wide CRISPRi screens in a damage-sensitized...

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Source

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Identifiers

PMID: 42236937
DOI: 10.1038/s41586-026-10604-6
PMCID: PMC13442042

Genes

TFG
GABARAP
TSG101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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