Article

OptoGranules reveal the evolution of stress granules to ALS-FTD pathology

2018-06-15

Abstract excerpt

Stress granules are non-membranous assemblies of mRNA and protein that form in response to a variety of stressors. Genetic, pathologic, biophysical and cell biological studies have implicated disturbances in the dynamics of membrane-less organelles, such as stress granules, as a pathobiological component of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) 1–12 . This confluence of evidence ha...

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Literature Corpus work: fd685b71-edca-58ad-b7fe-4a6be71a7c45
DOI: 10.1101/348870

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