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Article

Sealing and healing: A two-step model for plasma membrane repair.

Developmental cell - 8 Jul 2026

Kournoutis Athanasios, Stenmark Harald

Abstract excerpt

Plasma membrane damage can cause cell death and is associated with neurodegeneration. In this issue of Developmental Cell, Heffner et al. show that annexin A11 (ANXA11) first plugs membrane lesions, before ESCRT-III is recruited to extrude the damaged patch-a two-step repair mechanism compromised by ALS- and FTD-linked mutations.

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Identifiers

PMID: 42419281
DOI: 10.1016/j.devcel.2026.06.011

Genes

ANXA11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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