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Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

20 Mar 2019

Abstract excerpt

Stress granules (SGs) are non-membrane-bound RNA-protein granules that assemble through phase separation in response to cellular stress. Disturbances in SG dynamics have been implicated as a primary driver of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), suggesting the hypothesis that these diseases reflect an underlying disturbance in the dynamics...

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PMID: 30893049
DOI: 10.7554/elife.39578

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