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ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains

29 Jul 2025

Abstract excerpt

The cellular response to lysosomal damage involves fine-tuned mechanisms of membrane repair, lysosome regeneration and lysophagy, but how these different processes are coordinated is unclear. Here we show in human cells that the deubiquitinating enzyme ATXN3 helps restore integrity of the lysosomal system after damage by targeting K48-K63-branched ubiquitin chains on regenerating lysosomes. We find that ATXN3 is...

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PMID: 40730717
DOI: 10.1038/s44318-025-00517-x

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