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Article

Landscape of genetic alterations affecting cancer genes in primary and advanced malignant phyllodes tumours.

Histopathology - 1 Oct 2026

Yeni Yildirim Selma, Selenica Pier, Gazzo Andrea, Djerroudi Lounes, Ross Dara, Brogi Edi, Weigelt Britta, Pareja Fresia

Abstract excerpt

BACKGROUND: Malignant phyllodes tumours (MPT) are aggressive breast fibroepithelial neoplasms. Their rarity has limited their genetic characterization, and associations with genetic ancestry and progression drivers remain poorly understood. Prior studies suggest two evolutionary pathways according to MED12 mutational status. We sought to determine the repertoire of somatic genetic alterations in cancer genes in...

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Topics

Humans
Phyllodes Tumor
Female
Breast Neoplasms
Mutation
Mediator Complex

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cyclin-Dependent Kinase Inhibitor p16

Adult

Middle Aged

Cyclin-Dependent Kinase Inhibitor p15

Neoplasm Recurrence, Local

Source

Open in PubMed Open full text

Identifiers

PMID: 42236264
DOI: 10.1111/his.70197
PMCID: PMC13551129

Genes

MED12
CDKN2A
EGFR
PIK3CA
PTEN
RB1
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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