Article
Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2021
Ng Cedric Chuan Young, Md Nasir Nur Diyana, Loke Benjamin Nathanael, Tay Timothy Kwang Yong, Thike Aye Aye, Rajasegaran Vikneswari, Liu Wei, Lee Jing Yi, Guan Peiyong, Lim Abner Herbert, Chang Kenneth Tou En, Gudi Mihir Ananta, Madhukumar Preetha, Tan Benita Kiat Tee, Tan Veronique Kiak Mien, Wong Chow Yin, Yong Wei Sean, Ho Gay Hui, Ong Kong Wee, Yip George Wai Cheong, Bay Boon Huat, Tan Patrick, Teh Bin Tean, Tan Puay Hoon
Abstract excerpt
Breast fibroepithelial lesions are biphasic tumors which comprise the common benign fibroadenomas (FAs) and the rarer phyllodes tumors (PTs). This study analyzed 262 (42%) conventional FAs, 45 (7%) cellular FAs, and 321 (51%) benign PTs contributed by the International Fibroepithelial Consortium, using a previously curated 16 gene panel. Benign PTs were found to possess a higher number of mutations, and higher...
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