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Genomic landscape of malignant phyllodes tumors reveals multiple targetable opportunities.

The oncologist - 6 Dec 2024

Rosenberger Laura H, Riedel Richard F, Diego Emilia J, Nash Amanda L, Grilley-Olson Juneko E, Danziger Natalie A, Sokol Ethan S, Ross Jeffrey S, Sammons Sarah L

Abstract excerpt

BACKGROUND: Malignant phyllodes tumors (MPT) are rare fibroepithelial breast cancers with no known effective systemic therapy; metastatic progression portends a dismal prognosis. We sought to describe the genomic landscape of MPTs through genomic profiling and immunotherapeutic biomarker analysis. MATERIALS AND METHODS: Cases of sequenced MPT were identified from a Clinical Laboratory Improvement...

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Source

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Identifiers

PMID: 39191445
DOI: 10.1093/oncolo/oyae218
PMCID: PMC11630793

Genes

NF1
PIK3CA
BRAF
CDKN2A
CDKN2B
EGFR
KMT2D
MED12
MTAP
PTEN
RB1
TERT
TP53

Variants

Provenance

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Related research

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Genomic landscape of malignant phyllodes tumors reveals multiple targetable opportunities.PMID 39191445Read ↗

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Circulating Tumor DNA (ctDNA) is Reliably Detected in Patients with Metastatic Malignant Phyllodes Tumors, a Feasibility Study.Semantic proximity Read ↗

Genomic Analysis of Advanced Phyllodes Tumors Using Next-Generation Sequencing and Their Chemotherapy Response: A Retrospective Study Using the C-CAT Database.Semantic proximity Read ↗

Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing.Semantic proximity Read ↗

Genomic Analysis of Advanced Phyllodes Tumors Using Next-Generation Sequencing and Their Chemotherapy Response: A Retrospective Study Using the C-CAT DatabaseSemantic proximity Read ↗

Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression.Semantic proximity Read ↗

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Phyllodes Tumors: Diagnostic, Investigative and Therapeutic Challenges with Special Focus on Malignant Phyllodes TumorsSemantic proximity Read ↗

Genetic Profiling of Mammary Periductal Stromal Tumors With Histologic Correlation Highlights High-Grade and Low-Grade Groups and Similarities to Phyllodes Tumors.Semantic proximity Read ↗

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