Article
Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors.
Molecular cancer research : MCR - 1 Apr 2015
Cani Andi K, Hovelson Daniel H, McDaniel Andrew S, Sadis Seth, Haller Michaela J, Yadati Venkata, Amin Anmol M, Bratley Jarred, Bandla Santhoshi, Williams Paul D, Rhodes Kate, Liu Chia-Jen, Quist Michael J, Rhodes Daniel R, Grasso Catherine S, Kleer Celina G, Tomlins Scott A
Abstract excerpt
UNLABELLED: Phyllodes tumors are rare fibroepithelial tumors with variable clinical behavior accounting for a small subset of all breast neoplasms, yet little is known about the genetic alterations that drive tumor initiation and/or progression. Here, targeted next-generation sequencing (NGS) was used to identify somatic alterations in formalin-fixed paraffin-embedded (FFPE) patient specimens from malignant,...
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