Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MED12 is frequently mutated in breast phyllodes tumours: a study of 112 cases.

Journal of clinical pathology - 1 Sept 2015

Ng Cedric Chuan Young, Tan Jing, Ong Choon Kiat, Lim Weng Khong, Rajasegaran Vikneswari, Nasir Nur Diyana Md, Lim Jeffrey Chun Tatt, Thike Aye Aye, Salahuddin Syed Ahmed, Iqbal Jabed, Busmanis Inny, Chong Angela Phek Yoon, Teh Bin Tean, Tan Puay Hoon

Abstract excerpt

AIM: To determine the frequency of MED12 mutations in a series of 112 breast phyllodes tumours, and to correlate the findings with clinicopathological parameters and survival outcomes. METHODS: Phyllodes tumours from the Department of Pathology, Singapore General Hospital, were classified into benign, borderline and malignant categories. Genomic DNA from formalin-fixed paraffin-embedded phyllodes tumours was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease-Free Survival

Share to DNA Mutational Analysis

Share to High-Throughput Nucleotide Sequencing

Share to Kaplan-Meier Estimate

Share to Mediator Complex

Share to Proportional Hazards Models

Source

Identifiers

PMID: 26018969
DOI: 10.1136/jclinpath-2015-202896

Genes

MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MED12 is frequently mutated in breast phyllodes tumours: a study of 112 cases.PMID 26018969Read ↗

Frequent MED12 mutations in phyllodes tumours of the breast.Semantic proximity Read ↗

Molecular pathology of phyllodes tumours of the breast-much more than MED12.Semantic proximity Read ↗

MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast.Semantic proximity Read ↗

MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways.Semantic proximity Read ↗

Mutational analysis of MED12 in fibroadenomas and phyllodes tumors of the breast by means of targeted next-generation sequencing.Semantic proximity Read ↗

Frequency of MED12 mutations in phyllodes tumors: Inverse correlation with histologic grade.Semantic proximity Read ↗

MED12 exon 2 mutations in phyllodes tumors of the breast.Semantic proximity Read ↗

Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis.Semantic proximity Read ↗

MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression.Semantic proximity Read ↗

Phyllodes tumors with and without fibroadenoma-like areas display distinct genomic features and may evolve through distinct pathwaysSemantic proximity Read ↗

Genetic and Clinical Characteristics of Phyllodes Tumors of the BreastSemantic proximity Read ↗

Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.