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Phyllodes tumors with and without fibroadenoma-like areas display distinct genomic features and may evolve through distinct pathways

6 Oct 2017

Abstract excerpt

Abstract Breast fibroepithelial lesions (fibroadenomas and phyllodes tumors) are underpinned by recurrent MED12 exon 2 mutations, which are more common in fibroadenomas and benign phyllodes tumors. TERT promoter hotspot mutations have been documented in phyllodes tumors, and found to be more frequent in borderline and malignant lesions. Several lines of evidence suggest that a subset of phyllodes tumors might...

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PMID: 29043292
DOI: 10.1038/s41523-017-0042-6

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