Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two progressed malignant phyllodes tumors of the breast harbor alterations in genes frequently involved in other advanced cancers.

Orphanet journal of rare diseases - 16 Aug 2021

Reinisch Mattea, Kuemmel Sherko, Breit Elisabeth, Theuerkauf Ingo, Harrach Hakima, Schindowski Dorothea, Moka Detlef, Bettstetter Marcus, Bruzas Simona, Chiari Ouafaa

Abstract excerpt

BACKGROUND: The genomic landscape of phyllodes tumors (PTs) of the breast is not well defined, especially in patients with advanced disease. To shed light on this topic, paired primary and progressed tumor samples from two patients with malignant PTs were subjected to next-generation sequencing (NGS) followed by functional analysis of genetic alterations using two prediction tools. METHODS: The DNA of both the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasm Recurrence, Local

Source

Open in PubMed Open full text

Identifiers

PMID: 34399808
DOI: 10.1186/s13023-021-01986-z
PMCID: PMC8365991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two progressed malignant phyllodes tumors of the breast harbor alterations in genes frequently involved in other advanced cancers.PMID 34399808Read ↗

Analysis of recurrent molecular alterations in phyllodes tumour of breast: insights into prognosis and pathogenesis.Semantic proximity Read ↗

Genomic Analysis of Advanced Phyllodes Tumors Using Next-Generation Sequencing and Their Chemotherapy Response: A Retrospective Study Using the C-CAT DatabaseSemantic proximity Read ↗

Genetic and Clinical Characteristics of Phyllodes Tumors of the BreastSemantic proximity Read ↗

Genomic Analysis of Advanced Phyllodes Tumors Using Next-Generation Sequencing and Their Chemotherapy Response: A Retrospective Study Using the C-CAT Database.Semantic proximity Read ↗

Comprehensive characterization of malignant phyllodes tumor by whole genomic and proteomic analysis: biological implications for targeted therapy opportunitiesSemantic proximity Read ↗

Genomic landscape of malignant phyllodes tumors reveals multiple targetable opportunities.Semantic proximity Read ↗

Genetic alterations and their association with clinicopathologic characteristics in advanced breast carcinomas: focusing on clinically actionable genetic alterations.Semantic proximity Read ↗

Comparison of mutation profile between primary phyllodes tumors of the breast and their paired local recurrences.Semantic proximity Read ↗

Comprehensive genomic profiling of malignant phyllodes tumors of the breast.Semantic proximity Read ↗

Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing.Semantic proximity Read ↗

Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression.Semantic proximity Read ↗

Molecular pathology of phyllodes tumours of the breast-much more than MED12.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.