Article
Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression.
The Journal of pathology - 1 Mar 2016
Piscuoglio Salvatore, Ng Charlotte Ky, Murray Melissa, Burke Kathleen A, Edelweiss Marcia, Geyer Felipe C, Macedo Gabriel S, Inagaki Akiko, Papanastasiou Anastasios D, Martelotto Luciano G, Marchio Caterina, Lim Raymond S, Ioris Rafael A, Nahar Pooja K, Bruijn Ino De, Smyth Lillian, Akram Muzaffar, Ross Dara, Petrini John H, Norton Larry, Solit David B, Baselga Jose, Brogi Edi, Ladanyi Marc, Weigelt Britta, Reis-Filho Jorge S
Abstract excerpt
Phyllodes tumours (PTs) are breast fibroepithelial lesions that are graded based on histological criteria as benign, borderline or malignant. PTs may recur locally. Borderline PTs and malignant PTs may metastasize to distant sites. Breast fibroepithelial lesions, including PTs and fibroadenomas, are characterized by recurrent MED12 exon 2 somatic mutations. We sought to define the repertoire of somatic genetic...
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