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Near-Infrared Light-Inducible CRISPR-Cas12a/Tetrahedral DNA Nanosystem for Spatiotemporal Control of mtDNA Mutation Imaging and Gene Therapy.

Nano letters - 4 Feb 2026

Jiang Yuelin, Gao Haocheng, Ran Qianqian, Xian Yuezhong, Zhang Cuiling

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations are associated with tumor progression and metabolic dysregulation, yet their spatiotemporal visualization and selective therapeutic modulation remain challenging owing to their low abundance and mitochondrial double-membrane barrier. We report a near-infrared (NIR) light-inducible CRISPR-Cas12a/tetrahedral DNA nanosystem for spatiotemporally resolved imaging and editing of...

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Identifiers

PMID: 41557883
DOI: 10.1021/acs.nanolett.5c05621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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