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Article

Germline cancer predisposition variants and pediatric glioma: a population-based study in California.

Neuro-oncology - 9 Jun 2020

Muskens Ivo S, de Smith Adam J, Zhang Chenan, Hansen Helen M, Morimoto Libby, Metayer Catherine, Ma Xiaomei, Walsh Kyle M, Wiemels Joseph L

Abstract excerpt

BACKGROUND: Pediatric astrocytoma constitutes a majority of malignant pediatric brain tumors. Previous studies that investigated pediatric cancer predisposition have primarily been conducted in tertiary referral centers and focused on cancer predisposition genes. In this study, we investigated the contribution of rare germline variants to risk of malignant pediatric astrocytoma on a population level. METHODS: DNA...

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Identifiers

PMID: 31970404
DOI: 10.1093/neuonc/noaa014
PMCID: PMC7283023

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