Clinical Impact of Germline Multigene Sequencing in Pediatric Cohorts with a Wide Spectrum of Neoplasms.

doi:10.3390/ijms27146395

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Article

Clinical Impact of Germline Multigene Sequencing in Pediatric Cohorts with a Wide Spectrum of Neoplasms.

International journal of molecular sciences - 18 Jul 2026

Semenova Vera, Zhukovskaya Elena, Zelenova Ekaterina, Kozlova Valentina, Krasnov George, Levashov Andrey, Sagoyan Garik, Belysheva Tatiana, Kharchikov Dmitriy, Suleymanova Amina, Ivanova Natalia, Lozovaya Anastasia, Rubanskaya Marina, Gelfer Svetlana, Sharapova Elena, Mikhaylova Svetlana, Valiev Timur, Karelin Alexander, Varfolomeeva Svetlana, Nasedkina Tatiana

Abstract excerpt

Cancer predisposition syndromes (CPSs) account for 8.5-18% of all childhood cancer cases. Most of them are inherited in an autosomal dominant pattern; consequently, there is a 50% risk of transmission to offspring. Early detection of CPSs is crucial for choosing patient treatment strategies and for counseling in the family. This study enrolled 886 pediatric patients with hematologic and solid neoplasms from...

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Identifiers

PMID: 42511739
DOI: 10.3390/ijms27146395
PMCID: PMC13410190

Genes

NF1
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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