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Germline analysis of an international cohort of pediatric diffuse midline glioma patients

12 Mar 2025

Abstract excerpt

BACKGROUND: Factors that drive the development of diffuse midline gliomas (DMG) are unknown. Our study aimed to determine the prevalence of pathogenic/likely pathogenic (P/LP) germline variants in pediatric patients with DMG. METHODS: We assembled an international cohort of 252 pediatric patients with DMG, including diffuse intrinsic pontine glioma (n = 153), with germline whole genome or whole exome sequencing....

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PMID: 40072012
DOI: 10.1093/neuonc/noaf061

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