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Article

Germline Variants in Cancer Predisposition Genes in Pediatric Patients with Central Nervous System Tumors.

International journal of molecular sciences - 12 Dec 2023

Jovanović Aleksa, Tošić Nataša, Marjanović Irena, Komazec Jovana, Zukić Branka, Nikitović Marina, Ilić Rosanda, Grujičić Danica, Janić Dragana, Pavlović Sonja

Abstract excerpt

Central nervous system (CNS) tumors comprise around 20% of childhood malignancies. Germline variants in cancer predisposition genes (CPGs) are found in approximately 10% of pediatric patients with CNS tumors. This study aimed to characterize variants in CPGs in pediatric patients with CNS tumors and correlate these findings with clinically relevant data. Genomic DNA was isolated from the peripheral blood of 51...

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Identifiers

PMID: 38139220
DOI: 10.3390/ijms242417387
PMCID: PMC10744041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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