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Genetic syndromes predisposing to pediatric brain tumors

13 Feb 2021

Abstract excerpt

Abstract The application of high-throughput sequencing approaches including paired tumor/normal sampling with therapeutic intent has demonstrated that 8%-19% of pediatric CNS tumor patients harbor a germline alteration in a classical tumor predisposition gene (NF1, P53). In addition, large-scale germline sequencing studies in unselected cohorts of pediatric neuro-oncology patients have demonstrated novel...

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PMID: 34277017
DOI: 10.1093/nop/npab012

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