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Article

Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2001

Ranganathan R, Sawin E R, Trent C, Horvitz H R

Abstract excerpt

We isolated two mutants defective in the uptake of exogenous serotonin (5-HT) into the neurosecretory motor neurons of Caenorhabditis elegans. These mutants were hypersensitive to exogenous 5-HT and hyper-responsive in the experience-dependent enhanced slowing response to food modulated by 5-HT. The two allelic mutations defined the gene mod-5 (modulation of locomotion defective), which encodes the only serotonin...

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Identifiers

PMID: 11487610
PMCID: PMC6763176

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