Gastrointestinal dysfunction in patients and mice expressing the autism‐associated R451C mutation in neuroligin‐3

Abstract excerpt

Abstract Gastrointestinal (GI) problems constitute an important comorbidity in many patients with autism. Multiple mutations in the neuroligin family of synaptic adhesion molecules are implicated in autism, however whether they are expressed and impact GI function via changes in the enteric nervous system is unknown. We report the GI symptoms of two brothers with autism and an R451C mutation in Nlgn3 encoding the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autism Spectrum Disorder Research
• Share to Child Nutrition and Feeding Issues
• Share to Gastrointestinal motility and disorders