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Article

Enhanced Molecular Staging of Pancreatic Cancer Using Methylated DNA Markers in Peritoneal Lavage Fluid.

Journal of surgical oncology - 1 Aug 2026

Mills Krystal, Berger Calise K, Taylor William R, Mahoney Douglas W, Burger Kelli N, Maheshwari Kalika, Kipp Benjamin R, Delgado Adriana M, Doering Karen A, Streich Heather M, Foote Patrick H, Cleary Sean P, Grotz Travis E, Kendrick Micheal L, Smoot Rory L, Starlinger Patrick P, Thiels Cornelius A, Truty Mark J, Warner Susanne G, Kisiel John B, Majumder Shounak

Abstract excerpt

BACKGROUND AND OBJECTIVES: Occult intra-abdominal metastases are identified in approximately 20% of patients with radiographically localized pancreatic ductal adenocarcinoma (PDAC) through staging laparoscopy, as peritoneal cytology is limited in sensitivity. Methylated DNA markers (MDMs) have demonstrated high diagnostic accuracy for PDAC in tumor tissue, blood, and pancreatic secretions. This study assesses the...

Topics

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Aged, 80 and over
Ascitic Fluid
Biomarkers, Tumor
Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Methylation

Neoplasm Staging

Pancreatic Neoplasms

Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 42226556
DOI: 10.1002/jso.70292
PMCID: PMC13427105

Genes

B3GALT6
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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