Article
Molecular Peritoneal Staging for Pancreatic Ductal Adenocarcinoma Using Mutant KRAS Droplet-Digital Polymerase Chain Reaction: Results of a Prospective Clinical Trial.
Journal of the American College of Surgeons - 1 Jul 2021
Yonkus Jennifer A, Alva-Ruiz Roberto, Abdelrahman Amro M, Leiting Jennifer L, Schneider Amber R, Grotz Travis E, Cleary Sean P, Smoot Rory L, Nagorney David M, Kendrick Michael L, Kipp Benjamin R, Truty Mark J
Abstract excerpt
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with predilection for peritoneal dissemination. Accurate peritoneal staging is imperative for treatment recommendations, as one-third of patients develop peritoneal recurrence after resection. Because >90% of PDAC tumors harbor mutant KRAS (mKRAS), we sought to determine feasibility of mKRAS DNA detection in peritoneal lavage (PL)...
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