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New DNA Methylation Markers for Pancreatic Cancer: Discovery, Tissue Validation, and Pilot Testing in Pancreatic Juice

28 May 2015

Abstract excerpt

PURPOSE: Discriminant markers for pancreatic cancer detection are needed. We sought to identify and validate methylated DNA markers for pancreatic cancer using next-generation sequencing unbiased by known targets. EXPERIMENTAL DESIGN: At a referral center, we conducted four sequential case-control studies: discovery, technical validation, biologic validation, and clinical piloting. Candidate markers were...

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Share to Epigenetics and DNA Methylation
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PMID: 26023084
DOI: 10.1158/1078-0432.ccr-14-2469

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