Article
Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA
25 Nov 2022
Abstract excerpt
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has the lowest overall survival rate primarily due to the late onset of symptoms and rapid progression. Reliable and accurate tests for early detection are lacking. We aimed to develop a noninvasive test for early PDAC detection by capturing the circulating tumour DNA (ctDNA) methylation signature in blood. METHODS: Genome-wide methylation profiles were...