Article
A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2020
Yang Zijian, LaRiviere Michael J, Ko Jina, Till Jacob E, Christensen Theresa, Yee Stephanie S, Black Taylor A, Tien Kyle, Lin Andrew, Shen Hanfei, Bhagwat Neha, Herman Daniel, Adallah Andrew, O'Hara Mark H, Vollmer Charles M, Katona Bryson W, Stanger Ben Z, Issadore David, Carpenter Erica L
Abstract excerpt
PURPOSE: To determine whether a multianalyte liquid biopsy can improve the detection and staging of pancreatic ductal adenocarcinoma (PDAC). EXPERIMENTAL DESIGN: We analyzed plasma from 204 subjects (71 healthy, 44 non-PDAC pancreatic disease, and 89 PDAC) for the following biomarkers: tumor-associated extracellular vesicle miRNA and mRNA isolated on a nanomagnetic platform that we developed and measured by...
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