Article
Molecular diagnosis for detecting KRAS mutation in peritoneal washing fluid of pancreatic ductal adenocarcinoma.
Scientific reports - 17 Sept 2024
Shimane Gaku, Nakano Yutaka, Matsuda Sachiko, Kitago Minoru, Masugi Yohei, Nakamura Kohei, Nakamura Yuki, Yagi Hiroshi, Abe Yuta, Hasegawa Yasushi, Hori Shutaro, Tanaka Masayuki, Takemura Ryo, Nishihara Hiroshi, Kitagawa Yuko
Abstract excerpt
Positive peritoneal washing cytology is an indicator of poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC); however, its sensitivity is relatively low. This study evaluated the performance of peptide nucleic acid (PNA)-directed PCR clamping as a molecular-based peritoneal washing cytology for sensitive detection of KRAS mutation in PDAC. Intraoperative peritoneal washing fluid (IPWF) obtained...
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