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Article

Association of accelerated phenotypic aging, lifestyle and genetic risk with progression of cardiometabolic multimorbidity: a multi-state model analysis.

GeroScience - 1 Jun 2026

Shi Yunxin, Wu Hongxian, Pan Lulu, Liu Yahang, Huang Chen, Yu Yongfu, Qin Guoyou, He Leqi

Abstract excerpt

We aimed to use multi-state models to assess joint impacts of lifestyle and genetic risk with phenotypic age acceleration on cardiometabolic multimorbidity (CMM) trajectory, and to further explore whether phenotypic age acceleration mediates association between lifestyle and each transitions. We conducted a prospective cohort study included 365,573 adults free of cardiometabolic diseases (CMDs) at baseline in UK...

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Identifiers

PMID: 41037219
DOI: 10.1007/s11357-025-01895-0
PMCID: PMC13356138

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