Genetic diversity of the Plasmodium falciparum Pfs230 gene in four East African countries supports its potential as a malaria transmission‑blocking vaccine candidate.

doi:10.1186/s12936-026-05953-6

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Genetic diversity of the Plasmodium falciparum Pfs230 gene in four East African countries supports its potential as a malaria transmission‑blocking vaccine candidate.

Malaria journal - 1 Jun 2026

Kisambale Angelina J, Moshi Ramadhan, Pereus Dativa, Mbwambo Ruth B, Mandai Salehe S, Chacha Gervas A, Lyimo Beatus, Madebe Rashid A, Budodo Rule, Bakari Catherine, Semboja Hussein J, Petro Daniel A, Challe Daniel P, Aaron Sijenunu, Mbwambo Daniel, Lusasi Abdallah, Kajange Stella, Lazaro Samwel, Mandara Celine I, Seth Misago D, Kulohoma Benard W, Juma Gerald, Ishengoma Deus S

Abstract excerpt

BACKGROUND: The current wide-spread drug and insecticide resistance in malaria parasites and mosquito vectors reinforces the urgent need of innovative interventions such as stage-specific vaccines. Transmission-blocking vaccine (TBV) candidates, including Plasmodium falciparum Pfs48/45 and Pfs230 play an essential role in enabling parasite fertilization within mosquitoes. This study evaluated the genetic...

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PMID: 42226229
DOI: 10.1186/s12936-026-05953-6
PMCID: PMC13440157

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