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Article

Worldwide genetic diversity of Plasmodium vivax Pv47 is consistent with natural selection by anopheline mosquitoes.

Nature communications - 9 Aug 2025

Molina-Cruz Alvaro, Gonzalez-Ceron Lilia, Dwivedi Ankit, Torres Tran Zen B, Raytselis Nadia, Young Micah, Kamath Nitin, McNinch Colton, Su Xinzhuan, Ford Anthony, Ferreira Marcelo U, Arévalo-Herrera Myriam, Herrera Sócrates, Lo Eugenia, Silva Joana C, Barillas-Mury Carolina

Abstract excerpt

Pv47 is the Plasmodium vivax ortholog of Pfs47, a protein that allows the Plasmodium falciparum malaria parasite to evade mosquito immunity and adapt to diverse vectors. We analyzed global genetic diversity of Pv47 and compared it with Pfs47, finding that most common Pv47 polymorphisms are non-synonymous and cluster in regions similar to those in Pfs47. Pv47 domain 2 presents an excess of non-synonymous...

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Identifiers

PMID: 40783499
DOI: 10.1038/s41467-025-62680-3
PMCID: PMC12335571

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