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Article

Genetic diversity of transmission-blocking vaccine candidate Pvs48/45 in Plasmodium vivax populations in China.

Parasites & vectors - 1 Dec 2015

Feng Hui, Gupta Bhavna, Wang Meilian, Zheng Wenqi, Zheng Li, Zhu Xiaotong, Yang Yimei, Fang Qiang, Luo Enjie, Fan Qi, Tsuboi Takafumi, Cao Yaming, Cui Liwang

Abstract excerpt

BACKGROUND: The male gamete fertilization factor P48/45 in malaria parasites is a prime transmission-blocking vaccine (TBV) candidate. Efforts to develop antimalarial vaccines are often thwarted by genetic diversity of the target antigens. Here we evaluated the genetic diversity of Pvs48/45 gene in global Plasmodium vivax populations. METHODS: We determined 200 Pvs48/45 sequences collected from temperate and...

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Identifiers

PMID: 26627683
DOI: 10.1186/s13071-015-1232-4
PMCID: PMC4665908

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