Article
Genetic diversity of Plasmodium falciparum reticulocyte binding protein homologue-5, which is a potential malaria vaccine candidate: baseline data from areas of varying malaria endemicity in Mainland Tanzania.
Malaria journal - 27 Jan 2025
Kisambale Angelina J, Pereus Dativa, Mandai Salehe S, Lyimo Beatus M, Bakari Catherine, Chacha Gervas A, Mbwambo Ruth B, Moshi Ramadhan, Petro Daniel A, Challe Daniel P, Seth Misago D, Madebe Rashid A, Budodo Rule, Aaron Sijenunu, Mbwambo Daniel, Lusasi Abdallah, Kajange Stella, Lazaro Samwel, Kapologwe Ntuli, Mandara Celine I, Ishengoma Deus S
Abstract excerpt
BACKGROUND: The limited efficacy of the two recently approved malaria vaccines, RTS,S/AS01 and R21/Matrix- M™, highlights the need for alternative vaccine candidate genes. Plasmodium falciparum Reticulocyte Binding Protein Homologue 5 (Pfrh5) is a promising malaria vaccine candidate, given its limited polymorphism, its essential role in parasite survival, a lack of immune selection pressure and higher efficacy...
Read the complete abstract on PubMedTopics
- Tanzania
- Genetic Variation
- Protozoan Proteins