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Article

Polymorphism in the gene encoding the Pfs48/45 antigen of Plasmodium falciparum. XI. Asembo Bay Cohort Project.

Molecular and biochemical parasitology - 1 Jan 2002

Escalante Ananias A, Grebert Heather M, Chaiyaroj Sansanee C, Riggione Flavia, Biswas Sukla, Nahlen Bernard L, Lal Altaf A

Abstract excerpt

We have investigated the genetic diversity of the gene encoding the transmission-blocking vaccine antigen Pfs48/45 of Plasmodium falciparum parasites from western Kenya and compared it with parasite populations from Thailand, India, and Venezuela. We report 44 complete new sequences. Overall, the antigen is less polymorphic as compared with other pre-erythrocytic and blood stage antigens. Contrary to other P....

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PMID: 11755182
DOI: 10.1016/s0166-6851(01)00386-3

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